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KMID : 0986520100100040220
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Korean Journal of Endoscrine Surgery
2010 Volume.10 No. 4 p.220 ~ p.223
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Preoperative Thyroid-stimulating Hormone Levels as a Predictor of Thyroid Carcinoma
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Joung Sung-Yup
Kim Hoon-Yub
Ryu Woo-Sang
Woo Sang-Wook
Son Gil-Soo
Lee Jae-Bok
Bae Jung-Won
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Abstract
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Purpose: This study investigated the effects of serum thyroid-stimulating hormone (TSH) levels in predicting malignancy-associated differentiated thyroid cancer (DTC) and benign thyroid nodules.
Methods: Between January 2005 and December 2007, 346 patients underwent thyroid surgery at one hospital. Their records were retrospectively reviewed.
Results: Sixty-nine percent (237 of 346) of the patients had DTC. The mean preoperative TSH level was higher than in the malignant group (5 uIU/ml vs 0.4 uIU/ml). The rate of malignancy was the 71% in patients with TSH levels ＞5 uIU/ml. The TSH level of DTC with metastasis of the lymph node was higher than that with non-metastasis (3.08 uIU/ml vs 2.09 uIU/ml, P＜0.01)
Conclusion: The likelihood of DTC increases with higher serum TSH concentration. Serum TSH level might be useful in predicting malignant nodular thyroid lesion.
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KEYWORD
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Thyroid carcinoma, Thyroid stimulating hormone, Differentiated thyroid cancer
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